Fatal rhino-orbito-cerebral infection caused by Saksenaea vasiformis in an immunocompetent individual: first case report from India.
نویسندگان
چکیده
A 56-year-old female patient presented with history of nasal blockage, nasal bleeding, headache, since one month. On admission the patient developed severe headache, decreased vision of eyes and blindness. Clinical diagnosis of rhino-orbital involvement was confirmed by computerized tomography of the paranasal sinuses. The diagnosis of fungal infection was confirmed by KOH examination, haematoxylin and eosin examination and Gomori's methanamine silver stain of the biopsy material. Diagnosis was confirmed by culture on Sabouraud Dextrose agar, slide culture on Czapek Dox medium and the isolate was identified as Saksenaea vasiformis. The patient was started on intravenous amphotericin B (received only one dose before succumbing), but she did not respond to the treatment, developed hemiparesis, slurred speech, diminished reflexes and ultimately died. The involvement of the brain was confirmed by computerised tomographic scan. We believe this case to be the first case of rhino-orbito-cerebral infection due to Saksenaea vasiformis and that of second case in an immunocompetent patient in the world.
منابع مشابه
[Necrotising fasciitis caused by Saksenaea vasiformis in an immunocompetent patient after a car accident].
BACKGROUND Cutaneous mucormycosis (zygomycosis), with subcutaneous spreading and dissemination, in immunocompetent patients is an uncommon disease caused by species belonging to the fungal genera Apophysomyces, Rhizopus and Saksenaea, among others. CASE REPORT A case of necrotising fasciitis by Saksenaea vasiformis in an immunocompetent woman is described. The infection was acquired through a...
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Rhino-orbito-cerebral mucormycosis is an uncommon aggressive life-threatening opportunistic fungal infection that affects mainly the immunocompromised population with mortality rate up to 50%. Due to its aggressive nature, early detection and prompt management are of great importance for a good prognosis. Our report describes a fatal outcome of a case of rhino-orbito-cerebral mucormycosis follo...
متن کاملRhino-Orbito-Cerebral Mucormycosis: A Case Report and Review of the Literature
Rhino-orbito-cerebral mucormycosis is a rare, opportunistic and often fatal fungal infection usually occurring in immuno-compromised or diabetic patients. The treatment involves administration of Amphotericin B and surgical debridement. Due to its lethal nature, early recognition of the infection is essential. This paper reports a case of rhino-orbito-cerebral mucormycosis, which developed in a...
متن کاملCutaneous zygomycosis: necrotising fascitis due to Saksenaea vasiformis.
Saksenaea vasiformis is an emerging human pathogen, most often associated with cutaneous or subcutaneous lesions following trauma. This is the report of a case of subcutaneous zygomycosis from which Saksenaea vasiformis was isolated on culture. As the patient developed acute interstitial nephritis, amphotericin B could not be administered in full dose. Surgical debridement was carried out, but ...
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ورودعنوان ژورنال:
- Indian journal of medical microbiology
دوره 26 4 شماره
صفحات -
تاریخ انتشار 2008